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Malignant soft tissue tumors of nerve sheath origin
Author(s) -
Nambisan R. N.,
Rao U.,
Moore R.,
Karakousis C. P.
Publication year - 1984
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930250410
Subject(s) - medicine , surgery , soft tissue , disease , nerve sheath , resection , sciatic nerve , schwannoma
Abstract Thirty‐one patients with neurogenic sarcomas treated at Roswell Park Memorial Institute (RPMI) during a 10‐year period were studied. The mean follow‐up is 35.5 months. A specific nerve of origin could not be identified in 61.3% of patients. The most frequent site was the proximal lower extremity (38.7%). The only presenting symptom was enlarging mass in 67.7%. There was association with Von Recklinghausen's disease in 42% of the cases. Survival was significantly worse in tumors with Von Recklinghausen's disease (25.6%) compared to patients with solitary malignant schwannomas (50.9%). Twelve of 18 patients who had adequate surgical treatment initially remain disease‐free, whereas only 2 of 11 patients referred following partial excision or recurrence remain disease‐free ( P < 0.02). Eleven of 18 patients with grade I or II tumor are disease‐free, whereas 2 of 10 patients with grade III tumor are diseasefree ( P < 0.05). Resection of the sciatic nerve with wide excision is accompanied with a good functional result.