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Immunity in esophageal carcinoma
Author(s) -
Advani S. H.,
Kutty P. M.,
Gopal R.,
Swaroop S.,
Nair C. N.,
Dinshaw K. A.,
Damle S. R.,
Nadkarni J. S.,
Akolkar P. N.,
Gothaskar B. P.,
Vyas J. J.,
Desai P. B.
Publication year - 1983
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930240406
Subject(s) - medicine , immunity , enteral administration , esophagus , carcinoma , immune system , sensitization , gastroenterology , cellular immunity , parenteral nutrition , immunology
In carcinoma of the esophagus, response to in vivo sensitization with recall antigens and DNCB was markedly depressed with 13% and 16% positivity respectively. Similarly, the number of T‐cells was found to be significantly low (24 ± 14) as compared to normal control (61 ± 23). Blastogenesis index with PHA was only 1.75 ± 1.04 in contrast to normal of 6.79 ± 2.57. This depression was independent of serum albumin level and body weight. Cell‐mediated immunity was further depressed following radiotherapy and did not improve following enteral alimentation for 3 weeks. In untreated patients, there was a significant rise in levels of IgA (298 ± 184 mg/100 ml) as compared to normal (154 ± 54 mg/100 ml). Levels of IgA did show a downward trend following enteral hyperalimentation. Circulating immune complexes and serum CEA level were elevated in almost 50% of patients. These data confirm the influence of tumor‐related impairment of cell‐mediated immunity while nutrition appears to affect IgA levels.