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Experimental cancer of the bowel in the Nb rat
Author(s) -
Joehl Raymond J.,
Drago Joseph R.
Publication year - 1983
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930240205
Subject(s) - medicine , carcinogen , cancer , colorectal cancer , animal model , gastroenterology , experimental animal , intestinal cancer , pathology , biology , biochemistry , veterinary medicine
Abstract An animal model of bowel cancer, induced by 1,2‐dimethyl hydrazine, has been developed in the Nb rat. Invasive polypoid carcinomas of the colon were noted in nine rats surviving 29 weeks after the carcinogen was first administered. Two of these nine rats also developed duodenal carcinomas. Because dosage schedules are known from previous experiments with the Nb rat, this animal model may be useful for evaluating the effects of cytotoxic drugs on experimental bowel cancer.