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Nb rat prostate adenocarcinoma model androgen‐sensitive tumor: Metastasis control
Author(s) -
Drago Joseph R.,
Weed Patti,
Fralisch Anne
Publication year - 1983
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930240108
Subject(s) - medicine , metastasis , castration , prostatic adenocarcinoma , cyclophosphamide , heparin , androgen , prostate cancer , prostate , adenocarcinoma , oncology , urology , chemotherapy , cancer , hormone
In this preliminary report, evaluation of nontraditional agents has been used to evaluate control of metastasis. This androgen‐sensitive rat prostic adenocarcinoma has been subject to the treatments of heparin, indocin, and castration, as well as combinations of castration, heparin, indocin, and cyclophosphamide. Tumor volume, metastasis and determination of regression of primary tumor have been evaluated. Heparin and indocin both reduced metastasis without affecting tumor volume in this study. The combination of castration and cyclophosphamide was most effective in reducing tumor volume when compared to the other groups.