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Adriamycin extravasation: Surgical treatment and possible prevention of skin and soft‐tissue injuries
Author(s) -
Pitkänen Jaakko,
AskoSeljavaara Sirpa,
Gröhn Pentti,
Sundell Börje,
Hein Erkki,
Appelqvist Pertti
Publication year - 1983
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930230409
Subject(s) - medicine , extravasation , surgery , lesion , soft tissue , dorsum , anesthesia , pathology , anatomy
In a material consisting of approximately 6,000 injections of Adriamycin during a 2‐year period, eleven moderate and five severe extravasation injuries have been observed. Even a small leakage of the drug may cause a permanent lesion. The most serious injuries were caused by large doses and on the dorsum of the hand. Plastic surgical operations were successfully performed in the severe cases. An active surgical intervention after primary neutralization of the extravasated Adriamycin is recommended.