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Blood flow in human tumors during hyperthermia therapy: Demonstration of vasoregulation and an applicable physiological model
Author(s) -
Olch Arthur J.,
Kaiser Larry R.,
Silberman Allan W.,
Storm F. Kristian,
Graham L. Stephan,
Morton Donald L.
Publication year - 1983
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930230217
Subject(s) - hyperthermia , blood flow , medicine , compartment (ship) , hyperthermia therapy , tumor cells , cancer research , biomedical engineering , oceanography , geology
A quantitative assessment of the effect of localized magnetic‐loop hyperthermia on blood flow was performed in 12 human tumors using the 133 Xe clearance method. Because blood flow in these tumors changed in response to needle injection, a physiologically based, one‐compartment model was developed that included both a hyperemic and a steady‐state component. In six tumors, changes in blood flow induced by heat were also observed. The ability of tumor vessels to respond dynamically to stress and the degree of response may be predictive of tumor heating capacity and subsequent therapeutic response.