Premium
The effects of cholestyramine, colestipol, and ADR‐132 on the rat prostate and dunning R‐3327 adenocarcinoma
Author(s) -
Brown William J.,
Karr James P.,
McGarry Michael,
Williams Phyllis D.,
Hagerman Larry M.,
Murphy Gerald P.
Publication year - 1983
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930220414
Subject(s) - cholestyramine , prostate , medicine , endocrinology , adenocarcinoma , hormone , cholesterol , cancer
The effects of three compounds known to have hypocholesterolemic activity in several species were investigated on the rat prostate and the hormone‐dependent R‐3327 rat prostatic adenocarcinoma. Cholestyramine, colestipol, and ADR‐132 are bile acid‐sequestering anion exchange resins which were fed to separate groups of adult male Copenhagen × Fischer (F 1 ) hybrid rats in doses of 0.25%, 1.00%, and 2.00% of diet. The results indicate that serum cholesterol levels in tumor‐bearing rats and controls fed these compounds for 29 days were not reduced. The body and organ weights as well as the histological features of the prostate gland, seminal vesicles, and the R‐3327 tumor were unaffected by these agents.