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The effect of pregnancy on hormone levels and receptors in malignant melanoma
Author(s) -
Sutherland Carl M.,
Wittliff James L.,
Fuchs Axel,
Mabie William C.
Publication year - 1983
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930220312
Subject(s) - medicine , pregnancy , melanoma , endocrine system , hormone , receptor , endocrinology , oncology , physiology , cancer research , biology , genetics
As previous studies indicate, some cases of malignant melanoma are clearly hormonally dependent as demonstrated by their stimulation by pregnancy and regression following delivery. A case of melanoma initiated during pregnancy and stimulated by a subsequent pregnancy was studied with biochemical receptor studies before and after endocrine manipulation. The negative steriod receptor studies obtained late in the patient's disease at time of endocrine manipulation predicted the lack of response. Results of this study indicate investigations are needed to define the relationship between malignant melanoma and pregnancy.