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Serum B 2 ‐microglobulin determinations in patients bearing soft tissue sarcomas
Author(s) -
Johnson Houston,
Flye M. Wayne
Publication year - 1983
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930220308
Subject(s) - beta 2 microglobulin , medicine , radioimmunoassay , soft tissue , sarcoma , gastroenterology , pathology , beta (programming language) , soft tissue sarcoma , endocrinology , computer science , programming language
To determine whether serum β 2 ‐microglobulin values could be useful as a tumor marker in patients with soft tissue sarcomas, 31 preoperative sera stored in our serum bank were assayed by radioimmunoassay for β 2 ‐microglobulin levels. Sera were selected from patients known to have large bulky tumors, but no evidence of other major systemic disorders. Thirty‐one sera of sex and age matched controls were assayed for compar ison. The laboratory range for normal serum β 2 ‐microglobulin values was 1.1‐2.4 mg/1. Our control patients had values ranging from 0.7‐1.7 mg/1. Values in tumor patients ranged from 0.7‐2.5 mg/1. No markedly elevated values were observed in any single patient. Four age groups, 20‐29, 30‐39, 40‐49, and 50‐59 years, revealed no significant differences. This observation differs from previously reported data. Serum β 2 ‐microglobu lin appears to have no value as a tumor marker in patients with soft tissue sarcomas. We were unable to substantiate findings by others that there is a significant increase in values of normal subjects corresponding to ad vancing age.