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Effect of splenectomy on the growth of murine colon tumors
Author(s) -
Sato Noriyuki,
Michaelides Maria C.,
Wallack Marc K.
Publication year - 1983
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930220202
Subject(s) - splenectomy , medicine , spleen , incidence (geometry) , pathology , metastatic tumor , solid tumor , gastroenterology , metastasis , cancer , physics , optics
We have previously demonstrated a high incidence of splenomegaly in BALB/c mice bearing colon tumor C‐C36, but not colon tumor C‐C26. To characterize this difference, tumor development in mice splenectomized seven days before tumor inoculation was compared to that of unoperated control mice. Our findings indicate that during the early phase, tumor growth is enhanced for both C‐C26 and C‐C36 in the splenectomized animals. The lag period for tumor appearance was also somewhat shorter in these splenectomized animals as compared to the controls, and metastatic tendency to the lungs was unaffected by splenectomy. These findings may have useful implications for the role of the spleen in the tumor‐bearing animal.