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The effect of total body microwave hyperthermia and hepatic artery ligation on liver tumors—an experimental study in rats
Author(s) -
Carlsson Goran,
Hafström Larsolof,
Hugander Anders,
Jönsson PerEbbe,
Bolmsjö Magnus,
Persson Bertil
Publication year - 1983
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930220110
Subject(s) - hyperthermia , medicine , liver tumor , ligation , adenocarcinoma , endocrinology , anesthesia , surgery , cancer , hepatocellular carcinoma
The effect of general microwave hyperthermia and hepatic artery ligation (HAL) was tested on Wistar rats with a transplanted N‐methyl‐N‐nitroso‐guanidine‐induced adenocarcinoma in the liver. Total body hyperthermia (41.5°C for 1 hour, three times during 24 hours) was given on the same day as HAL, and 1, 2, and 3 days after. HAL induced a slower tumor growth than untreated controls. No additive effect was registered when total body microwave hyperthermia was added to HAL. When hyperthermia was added 2 days after HAL, there was a transient decrease in tumor volume as in the HAL series. Total body microwave hyperthermia added 3 days after HAL induced a faster tumor growth than after HAL alone. When hyperthermia was added the same day and 1 day after HAL, there was a 50% mortality.