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Comparison of cytosol estrogen receptor status in ovarian carcinoma using different radiolabeled ligands and methods
Author(s) -
Lele S. B.,
Piver M. S.,
Barlow J. J.,
Chatterjee S.,
Schneider S.,
Ip M.
Publication year - 1982
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930210304
Subject(s) - estrogen receptor , estrogen , medicine , receptor , ovarian carcinoma , hormone , endocrinology , cytosol , ovary , hormone receptor , incubation , ovarian cancer , biology , cancer , biochemistry , breast cancer , enzyme
It is not uncommon to find more than one class of steroid hormone receptors present in a given tissue specimen. In this study we compared methods with different ligands and incubation conditions. Samples were also assayed using the dextran‐coated charcoal as well as sucrose gradient. The purpose of this paper is to show the need for a standardization of technique if we are to draw meaningful conclusions from the values obtained by different workers. Whereas normal ovaries and benign ovarian lesions lacked estrogen receptors, the presence of estrogen receptor was confirmed in malignant ovarian lesions.