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Concurrent chemotherapy and radiation therapy of selected head and neck squamous cell carcinomas using bleomycin and hydroxyurea: A southwest oncology group study
Author(s) -
Cruz Anatolio B.,
Perkins Matilda,
Aust J. Bradley,
Coltman Charles A.,
Pollard Ester B.,
Fletcher William S.,
Kennedy Peter,
Lehane Daniel E.,
Mira Joaquin,
McCracken Joseph D.,
Sorgen Stephen D.,
Page Carey P.,
Pendleton Olga J.,
Reddy Eashwer,
Sapp Joan,
Smith Frank
Publication year - 1982
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930200410
Subject(s) - mucositis , medicine , leukopenia , bleomycin , radiation therapy , chemotherapy , basal cell , oncology , head and neck , stage (stratigraphy) , toxicity , gastroenterology , surgery , paleontology , biology
Forty‐three patients with Stage III or IV squamous cell carcinoma of the head and neck were treated with simultaneous hydroxyurea and bleomycin in four treatment levels and with full‐dose radiotherapy. Complete responses ranged from 28 to 50% (P = .47), and complete plus partial responses ranged from 57 to 84% (P = .50), in a total of 33 patients. The primary toxicity was moderate to severe mucositis and minimal leukopenia. Despite good initial response, long‐term survival duration was not greater than was that for historical controls.