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Partial protection of the gastric toxicity of regional 5‐fluorouracil infusion by thymidine and cimetidine
Author(s) -
AlJurf Adel S.
Publication year - 1982
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930200309
Subject(s) - cimetidine , medicine , fluorouracil , chemotherapy , stomach , toxicity , histamine , pharmacology , thymidine , gastric acid , gastroenterology , basal (medicine) , in vitro , biochemistry , biology , insulin
Gastric ulceration resulted from regional (infusion) chemotherapy when high doses of 5‐fluorouracil were accidently infused into the stomach during hepatic artery infusions. A method for reproduction of those ulcers was established by gastric artery infusions. A trial to protect against such development with thymidine produced only partial protection. Measurement of gastric acid output in animals receiving one dose of 5‐fluorouracil showed no change in basal acid secretion but a significant decrease in histamine‐stimulated output. Partial protection from ulcer development was also accomplished with cimetidine alone.