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Localized magnetic‐loop induction hyperthermia of the rabbit brain
Author(s) -
Silberman Allan W.,
Morgan David F.,
Storm F. Kristian,
Rand Robert W.,
Bubbers J. Eric,
Brown W. Jann,
Morton Donald L.
Publication year - 1982
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930200308
Subject(s) - hyperthermia , medicine , brain tissue , rabbit (cipher) , skull , pathology , brain damage , anatomy , statistics , mathematics
The Magnetrode magnetic‐loop applicator has been used for deep internal hyperthermia with minimal toxicity and without normal tissue injury. Until now, the effects of localized radiofrequency hyperthermia on the brain have not been adequately studied because of the potential hazards involved in trying to effect brain heating while preserving overlaying surface tissues. We found that normal rabbit brain could be heated to potentially tumoricidal temperatures (42–43°C) without apparent histopathologic or clinical damage to brain, skull, external eye, subcutaneous tissue, or skin.