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Histologic changes seen in the hepatic parenchyma and in metastatic nodules following hepatic dearterialization
Author(s) -
Paris Allen L.,
Meissner William A.,
McDermott William V.
Publication year - 1982
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930190215
Subject(s) - medicine , parenchyma , blood supply , pathology , liver parenchyma , artery , fibrous capsule of glisson , necrosis , nodule (geology) , revascularization , ligation , hepatic tumor , surgery , biology , paleontology , myocardial infarction
Hepatic dearterialization was performed on four patients in an attempt to provide symptomatic relief from metastic carcinoma in the liver. Interruption of hepatic arterial blood supply causes necrosis in large metastatic tumor deposits, but very small nodules are unaffected by the procedure; this observation supports experimental studies on tumor angiogenesis factor. Interruption of hepatic arterial blood supply results in nonspecific ischemic changes to the hepatic parenchyma, which responds with small nests of regenerating liver cells. This finding appears to support the work of Plengvanit on revascularization of the liver after hepatic artery ligation.