Premium
Chemotherapy and pattern of metastases in breast cancer patients
Author(s) -
Amer Magid H.
Publication year - 1982
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930190212
Subject(s) - medicine , breast cancer , chemotherapy , autopsy , incidence (geometry) , cancer , disease , retrospective cohort study , meningeal carcinomatosis , meninges , oncology , metastasis , surgery , pathology , cerebrospinal fluid , physics , optics
A retrospective analysis of all breast cancer patients who died of their disease at Harper Grace Hospital during 1962 to 1976, was conducted to determine the pattern of metastases and its relation to chemotherapy. The autopsy incidence of distant metastases, to all organ sites, was noted to be higher among patients who previously received cytotoxic therapy, compared with those who did not. Such incidence was unrelated to differences in patients' age, menopausal status, and disease‐free interval. It is postulated that chemotherapy contributes to the wider metastases, especially to the central nervous system and meninges, in a breast cancer patient. This is possibly due to a longer survival of patients treated.