Premium
Effect of alkali metal salts on sarcoma I in A/J mice
Author(s) -
ElDomeiri Ali A.,
Messiha Fathy S.,
Hsia WenCheng
Publication year - 1981
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930180410
Subject(s) - caesium , potassium , sarcoma , alkali metal , lithium (medication) , lithium chloride , medicine , inhibitory postsynaptic potential , intracellular , incidence (geometry) , chloride , endocrinology , pharmacology , radiochemistry , chemistry , biochemistry , pathology , inorganic chemistry , physics , organic chemistry , optics
The chloride salts of lithium (Li + ) and cesium (Cs + ) were evaluated for their ability to influence the growth of Sarcoma I implants in A/J mice. The administration of daily doses of either 1 or 3 mEq/kg CsCl to these mice reduced the incidence and size of tumor implants. This effect was not apparent in animals receiving a smaller dose (0.5 mEq/kg) of the same drug. At the time of sacrifice the serum level of Cs + in this latter group was approximately half that recorded in animals receiving the higher doses of CsCl. No effect on tumor incidence or rate of growth was observed in animals receiving different doses of LiCl. Because of the similarities that existed between cesium and potassium, it was postulated that the effect of cesium was due to alterations in the intracellular composition of the tumor cells. Also, the possible role of cytotoxic agents in potentiating the inhibitory effect of cesium on tumors was discussed.