Mercury‐induced necrosis of murine renal cell carcinoma | Zendy

Herr Harry W. | Zendy; Kleinert Edward L. | Zendy; Whitmore Willet F. | Zendy

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Mercury‐induced necrosis of murine renal cell carcinoma

Author(s) -

Herr Harry W.,

Kleinert Edward L.,

Whitmore Willet F.

Publication year - 1981

Publication title -

journal of surgical oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.201

H-Index - 111

eISSN - 1096-9098

pISSN - 0022-4790

DOI - 10.1002/jso.2930180114

Subject(s) - nephrotoxicity , necrosis , mercury (programming language) , medicine , renal cell carcinoma , kidney , pathology , mercury poisoning , carcinoma , toxicity , cancer research , computer science , programming language

Administration of the nephrotoxic agent, bichloride of mercury (HgCl 2 ), to BALB/c mice bearing subcapsular renal tumor transplants induced early preferential necrosis of the tumor cells compared with mercury‐treated normal kidney tubular cells and untreated control tumors. The principle is established that a selective proximal tubular poison is also toxic for a tumor of the same cellular origin.

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