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Mercury‐induced necrosis of murine renal cell carcinoma
Author(s) -
Herr Harry W.,
Kleinert Edward L.,
Whitmore Willet F.
Publication year - 1981
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930180114
Subject(s) - nephrotoxicity , necrosis , mercury (programming language) , medicine , renal cell carcinoma , kidney , pathology , mercury poisoning , carcinoma , toxicity , cancer research , computer science , programming language
Abstract Administration of the nephrotoxic agent, bichloride of mercury (HgCl 2 ), to BALB/c mice bearing subcapsular renal tumor transplants induced early preferential necrosis of the tumor cells compared with mercury‐treated normal kidney tubular cells and untreated control tumors. The principle is established that a selective proximal tubular poison is also toxic for a tumor of the same cellular origin.