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Effect of major small bowel resection on dimethylhydrazine‐induced bowel carcinogenesis
Author(s) -
Harte P. J.,
Steele G.,
Rayner A. A.,
Munroe A. E.,
King V. P.,
Wilson R. E.
Publication year - 1981
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930180113
Subject(s) - medicine , resection , anastomosis , bowel resection , gastroenterology , 1,2 dimethylhydrazine , gastrointestinal tract , colorectal cancer , dimethylhydrazine , surgery , cancer
We have investigated the effect of distal small bowel resection on chemically induced tumors of the gastrointestinal tract in Wistar/Furth (W/Fu) rats. Dimethylhydrazine (DMH) (20 mg/kg sc once weekly × 16) was commenced 3 months after rats underwent resection of the distal 30 cm of small bowel (one‐third resection) or after sham small bowel resection (controls). Fifty weeks after the start of DMH administration, tumors were found in 15 of 25 animals who underwent small bowel resection compared to 9 of 31 animals in the control group (P<0.05). After small bowel resection, 8 of 15 tumors occurred at the site of anastomosis but no anastomotic tumors were seen after sham resection. In addition, tumors were larger and more invasive after small bowel resection. These data indicate that major small bowel resection potentiates DMH induced‐intestinal carcinogenesis.