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Hormone receptors in male breast carcinoma
Author(s) -
Ruff Stanley J.,
Bauer John E.,
Keenan Edward J.,
Moseley H. Stephens,
Fletcher William S.
Publication year - 1981
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930180109
Subject(s) - medicine , carcinoma , receptor , breast carcinoma , hormone , oncology , hormone receptor , gynecology , breast cancer , general surgery , cancer
It is well established that approximately 60% of female breast cancers contain estrogen receptors (ER+). The hormonal receptor status of male breast cancers remains relatively unknown. Tumor tissue from 14 patients has been reviewed at the University of Oregon Health Sciences Center. Specimens of all 14 patients were ER+ with a range of 5.5 to 374 fmol/mg protein. Eight of 12 patients had tumors which also contained progesterone receptors (PR+) with a range of 42 to 1852 fmol/mg protein. Nine patients were treated by modified radical mastectomy, two by radical mastectomy, one by simple mastectomy, and two by biopsies only. Twelve patients remain free of disease with a mean follow‐up of less than 2 years. The two patients who developed metastases both responded to endocrine ablation by orchiectorny and subsequent adrenalectomy. These data suggest that male breast cancer is highly endocrine sensitive and that endocrine ablation can play an integral part in those men unfortunate enough to develop disseminated disease.