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Pathology of metastasizing tumors in nitrosomethyl urea‐induced rat mammary carcinoma
Author(s) -
Ghosh Luna,
Nassauer Joyce,
Faiferman Isidore,
Ghosh Bimal C.
Publication year - 1981
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930180104
Subject(s) - mammary carcinoma , pathology , medicine , spleen , transplantation , bone marrow , mammary tumor , lung , mammary gland , primary tumor , metastasis , carcinoma , metastatic carcinoma , cancer , breast cancer
Abstract The metastatic capacity of rat mammary tumors induced with N‐nitrosomethyl urea was tested in BUF/N inbred female rats by successive transplantation. After the first and second passage, tumor cells appeared diffusely distributed throughout the bone marrow and spleen, confirming results reported by others; no other metastases were observed. After six successive transplantations, large, well‐defined tumor nodules were observed in the liver, spleen, lung, and the peritoneal surface of the intestines in 40% of the injected animals. The morphology of the primary and metastatic tumors was compared by light microscopy. The tumors appeared to be adenocarcinomas with differing degrees of differentiation. No morphlogical differences could be observed between the primary and the metastatic tumors.