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Ultrastructural study of membrane glycocalyx in primary and metastatic human and rat mammary carcinoma
Author(s) -
Ghosh Luna,
Nassauer Joyce,
Faiferman Isidore,
Ghosh Bimal C.
Publication year - 1981
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930170413
Subject(s) - glycocalyx , pathology , medicine , primary tumor , metastasis , metastatic carcinoma , ultrastructure , metastatic tumor , mammary carcinoma , immunohistochemistry , mammary gland , glycoprotein , staining , carcinoma , immunocytochemistry , breast carcinoma , biology , cancer , immunology , breast cancer , microbiology and biotechnology
Abstract The glycocalyx of primary and metastatic tumors was compared by ruthenium red staining and electron microscopy. Two systems were studied: human primary and metastatic breast tumors and rat primary and metastatic mammary carcinomas. A considerable diminution in the amount of glycocalyx was detected in both systems when primary tumors were compared with metastases. These results are consistent with observations of others showing that metastatic tumors shed glycoprotein antigens to the circulation; this may provide an immune escape mechanism for tumor cells, allowing their dissemination.