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Murine erythropoietin in ascitic fluid
Author(s) -
Fredrickson T. N.,
Lobue J.,
Camiscoli J. F.,
Gordon A. S.,
Spector D.
Publication year - 1981
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930170411
Subject(s) - ascites , ascitic fluid , erythropoietin , phenylhydrazine , hematocrit , medicine , irradiation , endocrinology , chemistry , medicinal chemistry , physics , nuclear physics
Administration of 0.2 ml of a 1.25% solution of phenylhydrazine (PHZ) and 500 rads of X‐irradiation to BALB/c mice produced a prompt and severe reduction to hematocrit with a resultant increase in plasma levels of erythropoietin (Ep). By also giving mice treated with PHZ and irradiation an ascites from of a transplantable sarcoma, the amount of recoverable material rich in Ep could be greatly increased because ascitic fluid contained levels of Ep comparable to plasma.