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Estradiol‐3‐dansylate used as a fluorescent histochemical stain, a possible prognostic aid for nondisseminating prostatic carcinoma
Author(s) -
van Dalen Johan P. R.
Publication year - 1981
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930170410
Subject(s) - medicine , stain , metastasis , staining , pathology , carcinoma , biopsy , prostate , prostate carcinoma , cancer
Transperineal biopsies of prostate carcinomas were histochemically stained with estradiol‐3‐dansylate, a fluorescent stain. About half of the carcinomas were stainable but carcinomas with distant metastasis showed a lower staining percentage than carcinomas without distant metastasis. The combination of a positive estradiol‐3‐dansylate staining and a well‐to‐moderate differentiation of the tumor seems to indicate a low chance of developing metastasis in the future. If this correlation could be confirmed in following studies, it would mean that about one‐third of patients with localized prostatic carcinoma may be indicated by a transperineal biopsy with this method, as having a low risk for future metastasis.