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Effect of cimetidine on human leukocyte function
Author(s) -
Majeski James A.,
Alexander J. Wesley
Publication year - 1981
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930170207
Subject(s) - cimetidine , medicine , function (biology) , immunology , pharmacology , microbiology and biotechnology , biology
Abstract In vitro studies of the effects of cimetidine on neutrophil and monocyte chemotaxis revealed no differences between the treated cells and control cells. In vitro studies were performed on neutrophils and monocytes from 20 patients who were treated with oral cimetidine for duodenal ulcer disease. Neutrophil studies from these patients revealed no effect by cimetidine. A significant augmentation of chemotaxis was found in monocytes from patients receiving the drug. Studies of neutrophil phagocytosis from cimetidine‐treated patients were exactly identical to control values. These studies indicate cimetidine to have a stimulatory effect on monocyte chemotaxis and no effect on neutrophil function.