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Immunological detection of metastases from prostatic adenocarcinoma
Author(s) -
Heaney John A.,
Lin Julia C.,
Daly James J.,
Prout George R.
Publication year - 1981
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930170113
Subject(s) - medicine , prostatic acid phosphatase , prostatic adenocarcinoma , adenocarcinoma , acid phosphatase , prostatectomy , prostate , prostate adenocarcinoma , pathology , biopsy , metastatic adenocarcinoma , needle biopsy , radiology , urology , cancer , enzyme , biochemistry , chemistry
In six patients with known prostatic adenocarcinoma, extraprostatic (metastatic) tumor was suspected on radiographic or radionucleotide studies. When cytological examination of tissue obtained by needle aspiration or biopsy was nondiagnostic, radial gel immunodiffusion was used to identify the presence of prostatic acid phosphatase in the tissue. Four specimens demonstrated prostate‐specific acid phosphatase activity, permitting the diagnosis of metastatic prostatic adenocarcinoma. The technique is simple and highly specific.