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Combination chemotherapy in a prostate tumor model: Nb rat prostatic adenocarcinoma model
Author(s) -
Drago Joseph R.,
Worgul Thomas,
Gershwin M. Eric
Publication year - 1981
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930160409
Subject(s) - medicine , prostatic adenocarcinoma , prostate , adenocarcinoma , chemotherapy , prostate adenocarcinoma , urology , oncology , cancer
This report presents the experience with single and combination chemotherapy in the Noble rat prostatic adenocarcinoma model. The best single agent in treatment of these tumors is cyclophosphamide, the best combination was triple drug therapy cyclophosphamide, cis‐plati‐num, and adriamycin. This report examines the effect of the various chemotherapeutic regimens on tumor volume, number of metastasis, and complete tumor regression.