Premium
Combination therapy for advanced malignant melanoma with BCNU, pseudomonas vaccine, and heparin
Author(s) -
Snyder R. D.,
Hortobagyi G. N.,
Bodey G. P.,
Gutterman J. U.,
Hersh E. M.
Publication year - 1981
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930160113
Subject(s) - medicine , melanoma , refractory (planetary science) , progressive disease , heparin , pseudomonas infection , oncology , chemotherapy , carmustine , surgery , pseudomonas , cyclophosphamide , cancer research , bacteria , physics , astrobiology , biology , genetics
A study was undertaken to investigate the addition of heparin and pseudomonas vaccine to BCNU in the treatment of patients with progressive malignant melanoma refractory to front‐line therapeutic regimens containing DTIC. Out of 27 evaluable patients, there was one partial remission (4%), and an additional ten patients (41%) had at least stable disease with a median survival time of 39 weeks compared to 15 weeks for those with progressive disease. The therapy was well tolerated. A schedule of pseudomonas vaccine that seemed to be tolerated has been established.