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Chemotherapy against human melanoma in the hamster cheek pouch
Author(s) -
Dufour Frank D.,
Okada Geoffrey T.,
Mah Stuart G.,
Morton Donald L.
Publication year - 1980
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930150409
Subject(s) - cheek pouch , medicine , methotrexate , melanoma , cheek , vincristine , hamster , dacarbazine , chemotherapy , neoplasm , surgery , pathology , cancer research , cyclophosphamide
Human malignant melanoma was transplanted to the cheek pouch of immuno‐suppressed (corticosteroid‐treated) hamsters. Significant differences were observed in tumor growth constants for animals treated with methotrexate, DTIC, BCNU, and vincristine (P < 0.05) compared to controls. However, no appreciable effect was demonstrated for Adriamycin, 5‐FU, and cytoxan. In addition, single doses as high as 400 mg/kg body weight of methotrexate were no more effective than other agents now used against this neoplasm.