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Enhancement of metastasis development by BCC lmmunotherapy
Author(s) -
Colmerauer Maria E.,
Koziol James A.,
Pilch Yosef H.
Publication year - 1980
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930150307
Subject(s) - medicine , metastasis , colorectal cancer , lung , primary tumor , survival rate , oncology , surgery , cancer
When BALB/c mice bearing growing transplants of a syngeneic colon carcinoma ‐ Colon Tumor 26 (CT 26) ‐ were treated with Bacillus Calmette‐Guerin (BCG), no effect on tumor growth rate or survival time was observed compared to untreated controls. However, after excision of primary tumor transplants, enhanced development of lung metastases was noted in the BCG‐treated mice, resulting in both an increased mortality rate (from metastatic disease) and a shorter survival time.