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Ultrastructural study of myoepithelial cells in breast carcinoma
Author(s) -
Ghosh Luna
Publication year - 1980
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930150105
Subject(s) - myoepithelial cell , ultrastructure , pathology , carcinoma , breast carcinoma , endoplasmic reticulum , medicine , microfilament , human breast , electron microscope , anatomy , biology , immunohistochemistry , cell , microbiology and biotechnology , cytoskeleton , breast cancer , cancer , physics , optics , genetics
This investigation was designed to study the myoepithelum of the human mammary carcinoma. Tissues were obtained from 30 infiltrating ductal carcinomas. Under light microscope, there were no significant changes noted in the myoepithelium. Glutaraldehyde‐fixed tissues were examined under electron microscope. In infiltrating carcinoma the myoepithelial cells contained increased endoplasmic reticulum, abundant microfilaments, secretory granules and intracytoplasmic duct formation. This observation suggests that myoepithelium takes an important and active role in the infiltrating stage of the human mammary carcinoma.