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Specific and aspecific immune responsiveness in lung cancer patients: Cutaneous delayed hypersensitivity reactions to a lung cancer‐associated antigen
Author(s) -
Sega Ercole,
Mottolese Marcella,
CordialiFei Paola,
Citro Gennaro,
Colizza Sergio,
Alcione Annamaria,
Paola Manolo Di
Publication year - 1980
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930140405
Subject(s) - medicine , lung cancer , antigen , immune system , lung , immunology , delayed hypersensitivity , cancer , pathology
The ability of a lung cancer‐associated antigen (LCAA) to provoke specific cutaneous delayed‐hypersensitivity reactions has been studied on a group of 59 lung cancer patients. Biological activity of LCAA, monitored by skin testing, was demonstrated in 32% (17 of 53) of lung cancer patients, in 48.0% with limited disease, and in 17.2% with extensive disease. All the responders were in the group of normal reactors to standard recall antigens, if three antigens were used (PPDSK‐SD, candida). No correlation was found between biological activity of LCAA and level of immunocompetence evaluated by lymphocyte‐blastic transformation with PHA and count of rosette E‐forming cells. These studies on the capacity to evoke specific DTH reactions in lung‐cancer patients will be extended to the use of assays in vitro in the perspective of a more significant evaluation of immunocompetence levels.