Premium
Serological evaluation of human brain tumors using a microradioisotopic staphylococcal protein a assay
Author(s) -
Cohen Alfred M.,
Wood William C.
Publication year - 1980
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930140306
Subject(s) - medicine , serology , astrocytoma , pathology , brain tumor , protein a , glioma , immunology , cancer research , antibody
A microradioisotopic staphylococcal protein A assay was applied to the serological evaluation of preoperative sera from brain tumor patients. The assay was performed in Terasaki plates, and a stainless steel punch and multiholed die facilitated sample prearation. Using allogeneic astrocytoma target cells, 15/19 of the brain tumor patients' sera were reactive, compared to 1/21 controls. 0/7 nonmalignant brain disease patients' sera were positve, and 5/20 sera from patients with epithelial malignancies. The brain tumor sera were not reactive against a rectal cancer cell line.