Serological evaluation of human brain tumors using a microradioisotopic staphylococcal protein a assay | Zendy

Cohen Alfred M. | Zendy; Wood William C. | Zendy

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Serological evaluation of human brain tumors using a microradioisotopic staphylococcal protein a assay

Author(s) -

Cohen Alfred M.,

Wood William C.

Publication year - 1980

Publication title -

journal of surgical oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.201

H-Index - 111

eISSN - 1096-9098

pISSN - 0022-4790

DOI - 10.1002/jso.2930140306

Subject(s) - medicine , serology , astrocytoma , pathology , brain tumor , protein a , glioma , immunology , cancer research , antibody

A microradioisotopic staphylococcal protein A assay was applied to the serological evaluation of preoperative sera from brain tumor patients. The assay was performed in Terasaki plates, and a stainless steel punch and multiholed die facilitated sample prearation. Using allogeneic astrocytoma target cells, 15/19 of the brain tumor patients' sera were reactive, compared to 1/21 controls. 0/7 nonmalignant brain disease patients' sera were positve, and 5/20 sera from patients with epithelial malignancies. The brain tumor sera were not reactive against a rectal cancer cell line.

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