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Effect of triiodothyronine and reserpine on induction and growth of mammary tumors in rats by 3‐methylcholanthrene
Author(s) -
Gerard Serge St.,
Gardner Bernard,
Patti Joseph,
Husain Vafarul,
Shouten Jeffrey,
Alfonso Antonio E.
Publication year - 1980
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930140305
Subject(s) - reserpine , methylcholanthrene , mammary tumor , triiodothyronine , stimulation , endocrinology , saline , medicine , mammary carcinoma , carcinogen , carcinoma , hormone , biology , cancer , breast cancer , genetics
This study was designed to investigate the effects of exogenous L‐triiodothyronine (LT 3 ) and reserpine administration on the induction and stimulation of 3‐methylcholanthrene (3‐MC) mammary tumors. Two hundred‐fifty‐eight 30‐day‐old virgin 100 gm Sprague Dawley rats were divided into eight groups. Groups I–IV received either reserpine, LT 3 , both, or saline 22 days after tumor induction with 3‐MC. Groups V–VIII were pretreated with either reserpine, LT 3 , or both for 29 days prior to tumor induction, and treatment was continued after tumor induction in all except Group VII. All rats were observed for tumor growth and sacrificed at seven months. Reserpine administration resulted in a protective effect against tumor induction in all groups in which it was used, with the most striking effects observed in the pretreated groups. Early LT 3 stimulation of tumor formation was reversed by simultaneous administration of reserpine. Prolonged administration was unnecessary when both agents were administered prior to 3‐methylcholanthrene.