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Serum immunoglobulins in colorectal cancer
Author(s) -
Slater Gary,
Papatestas Angelos E.,
Shafir Michail,
Aufses Arthur H.
Publication year - 1980
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930140210
Subject(s) - medicine , antibody , colorectal cancer , immune system , immunoglobulin a , gastroenterology , immunoglobulin m , carcinoma , immune status , stage (stratigraphy) , immunology , cancer , immunoglobulin g , paleontology , biology
Preoperative serum immunoglobulins were measured in 102 patients with colorectal carcinoma. There were no differences in the mean values of IgA, IgM or IgG between stages. There was an association, however, between advanced stage of disease and a combination of low levels of IgA (≤200 mg/dl) or high levels of IgM (≥125 mg/dl). The ratio of IgA/IgM was also found to be lower in advanced disease. It was felt that low levels of IgA and high IgM may represent an altered immune response and thus be a prognostic indicator.