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Association between estrogen receptors and weight in women with breast cancer
Author(s) -
Papatestas Angelos E.,
Panveliwalla Daraius,
Pertsemlidis Demetrius,
Mulvihill Michael,
Aufses Arthur H.
Publication year - 1980
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930130213
Subject(s) - medicine , breast cancer , estrogen receptor , estrogen , endocrine system , metastatic breast cancer , postmenopausal women , weight change , cancer , endocrinology , hormone , gynecology , physiology , weight loss , obesity
A significant association between body weight and estrogen receptor protein (ERP) was noted in 83 women with primary and metastatic breast cancer. Thirteen of 34 (54%) women with weight >150 lb had low or absent receptor protein (<10 femtomoles/mg of cytoplasmic protein) compared to 15 of 59 (25%) women with weight <150 lb (P <0.025). The observed association was stronger in the group of 62 postmenopausal women (P <0.01). The findings suggest that the endocrine and metabolic milieu in women with increased weight favors autonomous growth of breast cancer, and adjuvant treatment in this group should be planned accordingly.