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In vitro lymphocyte activity: Its relation to the stage of gastric cancer
Author(s) -
Tohgi Kimiaki,
Mashiba Harukazu,
Yoshinaga Hirokuni
Publication year - 1980
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930130111
Subject(s) - cytotoxicity , cancer , medicine , lymphocyte , stage (stratigraphy) , cytotoxic t cell , in vitro , immunology , cancer cell , cancer research , oncology , biology , biochemistry , paleontology
Lymphocyte activity of patients with gastric cancer and its relation to the stage of cancer were studied. PHA response of lymphocytes from patients with gastric cancer was decreased markedly even in early stage of cancer. The PHA‐stimulated lympho‐cytotoxicity was not impaired in all stages of the disease. Spontaneous lymphocyte‐mediated cytotoxicity showed a tendency to decrease as the cancer stage advanced. The cytotoxic activity of the supernatants from lymphocytes cultured without PHA was significantly high in the advanced stage of gastric cancer.