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Effect of acute and chronic ethanol intake on metastasis formation in rat liver
Author(s) -
Elmér Olle,
Göransson Göran,
Molander Nils
Publication year - 1979
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930120410
Subject(s) - medicine , ethanol , platelet , metastasis , endocrinology , platelet aggregation , cancer , gastroenterology , biochemistry , biology
The effect of acute ethanol intoxication and prolonged intake of ethanol on metastasis formation in the liver was studied in the rat. The tumour cells used were derived from a pharmacologically induced colon carcinoma (NGW 1) and were injected intraportally. Acute ethanol intoxication at the time of injection was associated with a liver weight of 13.29 ± 0.89 gm two weeks later, compared to 8.43 ± 0.51 gm in controls. Daily intake of ethanol for eight weeks resulted in a mild reduction of platelets. The liver weight in two groups was 7.31±0.50 gm and 12.19±1.40 gm three weeks after intraportal injection of cancer cells as compared to 9.53±1.11 gm and 19.63±1.67gm in controls. The results indirectly supported the hypothesis that acute ethanol intoxication causes increased platelet activity and confirmed earlier results showing the importance of platelets for metastasis formation.