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Ultrastructural localization of lactic dehydrogenase in mouse mammary carcinoma cells
Author(s) -
Ghosh Bimal C.,
Ghosh Luna,
Boarini Marla,
Newson Bobbie,
Das Gupta Tapas K.
Publication year - 1979
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930120406
Subject(s) - ultrastructure , lactic dehydrogenase , mammary carcinoma , cytoplasm , lactate dehydrogenase , mammary gland , mitochondrion , pathology , breast carcinoma , lactic acid , carcinoma , medicine , electron microscope , biology , microbiology and biotechnology , enzyme , biochemistry , breast cancer , cancer , bacteria , genetics , physics , optics
Electron microscopic study of lactic dehydrogenase (LDH) was carried out in C 3 H mouse mammary carcinoma cells. Scattered cytoplasmic LDH granules were noted as well as around mitochondria and nuclear membrane. Control studies with normal breast tissues failed to show any activity. This observation suggests that LDH plays an important role in C 3 H mammary carcinoma and may be of use as an additional marker.