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Effect of immunochemotherapy on lymphocyte response of patients with gastrointestinal cancer
Author(s) -
Mashiba Harukazu,
Yoshinaga Hirokuni,
Matsunaga Keiko,
Gojobori Mariko,
Furusawa Motonosuke
Publication year - 1979
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930120312
Subject(s) - medicine , gastrointestinal cancer , lymphocyte , immunology , oncology , cancer , colorectal cancer
Patients with gastrointestinal cancer were treated with 5‐fluorouracil (5‐FU) in combination with a streptococcal preparation, OK‐432, or without OK‐432 before operation, and lymphocyte response to PHA was examined. Oral administration of 5‐FU with or without intramuscular injection of OK‐432 did not affect the response. However, treatment with cytostatic drugs in combination with OK‐432 markedly augmented the lymphocyte response to PHA, but the cytotoxic activity of lymphocytes was not elevated.