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Adriamycin in localized and metastatic uterine sarcomas
Author(s) -
Piver M. Steven,
Barlow Joseph J.,
Lele Shashikant B.,
Yazigi Roberto
Publication year - 1979
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930120310
Subject(s) - medicine , chemotherapy , doxorubicin , metastasis , incidence (geometry) , distant metastasis , adjuvant chemotherapy , randomized controlled trial , adjuvant , surgery , oncology , cancer , breast cancer , physics , optics
Seventeen women with metastatic uterine sarcomas were treated with Adriamycin chemotherapy. Only one (6%) had an objective response. In addition, 12 patients with early uterine sarcomas were randomized to Adriamycin versus no adjuvant chemotherapy in order to evaluate the effect of Adriamycin in reducing the incidence of subsequent distant recurrences. Of those women receiving Adriamycin, two developed distant metastasis and two developed life‐threatening congestive heart failure. Also, two of the six women who did not receive Adriamycin developed distant metastasis. Therefore, continuation of the randomized trial was considered unjustified.