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Immunotherapy of a murine sarcoma using specific antitumor immune RNA
Author(s) -
Webster D. J. T.,
Cornacoff J. B.,
Vallera D. A.,
Dalmasso J. P.,
Dodd M. C.,
Minton J. P.
Publication year - 1979
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930120305
Subject(s) - fibrosarcoma , medicine , cytotoxicity , immunotherapy , in vivo , sarcoma , immune system , cancer research , in vitro , chemotherapy , rna , immunology , pathology , biology , biochemistry , microbiology and biotechnology , gene
The effect of IRNA therapy in a polyoma‐induced fibrosarcoma of C 3 H mice has been studied. Although a protocol that transferred in vitro cytotoxicity was used, no reduction in incidence of tumors, tumor size, or survival was demonstrated. In one experiment, enhancement of tumor growth occurred. It is concluded that cytotoxicity does not reflect in vivo changes and that therapeutic trials of IRNA are premature.