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Comparison of intramural 5‐fluorouracil and more conventional routes of drug administration on concentrations in gastric regional lymph nodes: A potential for trans‐endoscopic adjuvant chemotherapy
Author(s) -
Yamada Kazuki,
Murphy Gerald P.,
Douglass Harold O.
Publication year - 1979
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930110409
Subject(s) - medicine , chemotherapy , lymph , fluorouracil , drug , adjuvant , adjuvant chemotherapy , route of administration , surgery , oncology , gastroenterology , pharmacology , cancer , pathology , breast cancer
Intramural injection of 20 μCi (2‐ 14 C) 5‐fluorouracil(5‐FU) into the gastric submucosa of dogs and baboons was employed to evaluate the kinetics of 5‐FU distribution following this route of administration and to compare these results with those following intraluminal, intravenous, and local intra‐ arterial injections. Measurements of radioactivity taken over a six‐hour period after injections demonstrated that the greatest concentration of isotope in samples of gastric wall and perigastric lymph nodes was found after administration of the drug directly into the stomach wall. Clinical application of intramural injections of 5‐FU into the stomach wall under direct gastroscopic visual control, may be worthy of trial in patients with gastric cancer.