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Early tissue distribution of therapeutic 131 I in a patient with thyrotoxicosis
Author(s) -
Vachal E.,
Wegst A.,
Preston D.,
Tomita T.
Publication year - 1979
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930110402
Subject(s) - medicine , thyroid , spleen , pathology , radioiodine therapy , small intestine , follicular phase , distribution (mathematics) , nuclear medicine , thyroid cancer , mathematical analysis , mathematics
A therapeutic dose of 131 I was given to a 53‐year‐old man with thyrotoxicosis three and one‐half hours prior to death. The distribution of 131 I in the thyroid gland was studied by autoradiography, and the radioactivity in various fresh tissues was measured. Radioactivity was distributed evenly throughout the colloid;small amounts were present in follicular cells. Radioactivity was not localized to the periphery of colloid follicles as observed in an earlier report. Papillary projections were associated with increased radioactivity. Decreased ratioactivity was associated with oxyphilic cells. Measurement of 131 I in individual tissues showed that per gram of tissue the thyroid gland contained approximately 50 times that of intestine and spleen and approximately 100 times that of liver and bone.