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Assessment of myelotoxic effects of chemotherapy from early leukopenic response: Application of a mathematical model for granulopoiesis
Author(s) -
Blumenson Leslie E.,
Bross Irwin D.
Publication year - 1979
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930110211
Subject(s) - granulopoiesis , medicine , leukopenia , depression (economics) , oncology , cancer , chemotherapy , white blood cell , immunology , pharmacology , haematopoiesis , stem cell , biology , genetics , macroeconomics , economics
A recently developed model of the human granulopoietic system had been used to analyze the toxic effects of 5‐fluorouracil administered to cancer patients. From this analysis there appeared to be a relationship between the level of the early leukopenic depression and the rate at which the drug kills cells in the marrow. In particular, it may be possible to estimate this kill rate from the extent of the maximal depression in the white blood count during the second or third week after treatment begins. This estimate may be useful when planning modifications in treatment in order to prevent the onset of hematologic crises.