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Immunologic features of a carcinogen‐induced murine bladder cancer: In vivo and in vitro studies
Author(s) -
Javadpour N.,
Hyatt C. L.,
Soares T.
Publication year - 1979
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930110209
Subject(s) - in vivo , immunogenicity , in vitro , medicine , antigen , cytotoxic t cell , carcinogen , fetus , immunology , cancer , bladder cancer , cancer research , immunization , pathology , biology , pregnancy , biochemistry , genetics , microbiology and biotechnology
Certain in vivo and in vitro immunologic features of carcinogen‐induced murine bladder cancer have been studied. The consistency of tumor induction, its natural history, and immunogenicity both in vivo and in vitro render this syngeneic murine bladder tumor a suitable model for immunologic studies. Pre‐immunization of strain C3H/Hen mice with mid‐gestational fetal cells did not protect the animals from tumor challenge. Sera of mice immunized with mid‐gestational fetal cells were not cytotoxic to cultured tumor cells in a microcytotoxicity assay indicative of dissimilarity between the tumor associated antigen and the syngeneic mid‐gestational fetal antigen.