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Autoantigens in breast cancer tissue
Author(s) -
Humphrey L. J.,
Volenec P. J.,
Estes N. C.,
Volenec F. J.
Publication year - 1979
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930110208
Subject(s) - medicine , breast cancer , antigen , antibody , cancer , autoantibody , immunology , oncology
Two antigens in specimens of human breast cancer have been identified as autoantigens. One antigen appears to be an IgG Fc fragment; the other, an IgG Fab fragment. Antibodies in sera of cancer patients directed against these antigens have also been identified. These autoantibodies occur in patients with breast cancer as well as other cancers, and rarely in patients with non‐cancerous disease or in people screened in a detection center for breast diseases. The breast cancer patient found to have antibody directed against the IgG Fab antigen falls into a group that has improved two‐year survival statistics over groups of patients who lack this antibody.