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Explorations of antimitotic agents in the treatment of a congenital disease, Ichthyosis Linearis Circumflexa
Author(s) -
Klein Edmund,
Hahn Gary M.,
Solomon James A.,
Kim Untae,
Schwartz Robert A.,
Case Robert W.,
Herman Hannah,
Milgrom Halina,
Holtermann Ole A.
Publication year - 1979
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930110202
Subject(s) - medicine , disease , dermatology , pathology
Successful therapy of a genetic disorder, Ichthyosis Linearis Circumflexa, was achieved using low dose systemic cyclophosphamide. Prior to such therapy, 80 to 90% of the body surface was affected; the use of antimitotic agents reduced the extent of the lesions to less than 15% of the body surface. As a result, the clinical status was changed from severely disabling to being compatible with a normal way of life. It is believed that this phenomenon is related to selective effects of cyclophosphamide, such as those on lymphocyte subpopulations. To our knowledge, successful chemotherapy for diseases of genetic or congenital origin has not been previously reported.