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Immunocytological localization of estrogen in human mammary carcinoma cells by horseradish—anti‐horseradish peroxidase complex
Author(s) -
Ghosh Luna,
Ghosh Bimal C.,
Das Gupta Tapas K.
Publication year - 1978
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/jso.2930100308
Subject(s) - horseradish peroxidase , estrogen , cytoplasm , staining , hormone , nucleus , medicine , carcinoma , pathology , chemistry , biochemistry , enzyme , psychiatry
Tissues from 25 female and 2 male patients of mammary carcinoma were examined by the horseradish—anti‐horseradish peroxidase complex to localize the presence of estrogen. Carcinoma cells of 10 female and 2 male patients showed positive staining by this technique. The nucleus and the cytoplasmic membrane showed the reaction. This method is useful in identifying the exact location of the hormones or hormone‐like substances in the malignant cells and, perhaps, will be of great help in selecting the patients for management.